Bioprocess Engineering

Morphologic control in microbial cultivations

The physiological state of cells determines the yield of a process and is often liked to the morphological state. Cell morphology can be influenced by cell cycle, cultivation conditions or cell aging So there is a relationship between form and function. This is of great interest since morphology is easier to study and analyze in comparison to physiological, metabolic or genetic features.
This enables to use the appearance of the cells (shape, structure, form or chain formation), flocculation profiles and formation of agglomerates as key variables for process analyses and control. Moreover, in unicellular organisms like algae, yeast or bacteria the ratio of surface to the volume can play an important role for the adaptation to environmental conditions, like nutrient availability. The cell size is directly related to the internal biosynthesis. Not only is the size of the organelles often proportional to the cell size ( e.g. nucleus, mitochondria, vacuole), but also most of the proteins and mRNAs increase accordingly.

Running Projects

Project supervisor

Prof. Dr.-Ing. Stefan Junne

Contact person:

Simon Täuber (