Additive Manufacturing for Lab-on-Chip

The use of microelectronic chips in biological environments opens up prospects for extensive miniaturization. For various applications, the analyses previously performed in an entire laboratory could be brought together in a very small space, which is why the abbreviation Lab-on-a-Chip (LoC) has become established. In such LoC systems, e.g. cell suspensions are processed in microfluidic channels and directed to microscopically small mixing, lysis and analysis volumes. The latter may be equipped with microelectronic sensor chips, for which special integration or packaging concepts must then be developed.

3D printing or additive manufacturing processes in general have made integration processes much easier. In various projects such as the MRR-DEP biosensor or DEP-based cell separation, the required experimental systems are manufactured using AM processes. For this purpose, use is made of the many possibilities that exist for AM at the TU Berlin. The figure shows the exploded view of a microfluidic test system for microalgae separation by using the DEP effect [Barai et al. 2019].