Die Vorlesung „Einführung in die Bioelektronik“ findet jedes Sommersemester an der TU Berlin statt. Biotechnologen werden in die Grundlagen der Mikroelektronik eingeführt, die anhand von Anwendungsbeispielen aus Biologie und Medizin wie z.B. Membranpotential, EKG, Neurostimulation etc. veranschaulicht werden. Darüber hinaus finden Übungen statt, die die Lösung von internetbasierten Aufgaben und das Erlernen wichtiger EDV-Tools beinhalten. Letztere werden in einer wöchentlichen Übungsgruppe trainiert (z.B. CAD). Am Ende des Kurses können die Teilnehmer ein bioelektronisches System ihrer Wahl vorschlagen oder aus der Literatur auswählen, um es in einer Semesterarbeit mit den erlernten Methoden neu zu entwerfen und so die erlernten Techniken im eigenen Projekt anzuwenden. → zur Modulbeschreibung

At the end of each semester a practical course in bioelectronics is held. In a period of two weeks four experiments on the topics ECG, enzyme sensor, impedance cell sensor and microfluidic cell separation are completed. During these experiments, students learn how to handle simple electronic devices, 3D printers, microfluidic pumps and modern measurement and control systems based on single-board computers such as Arduino and Raspberry Pi. A detailed script serves as a thorough preparation. → module description

Due to the increasing interest in project work, more and more practical courses on bioelectronics are now being offered as part of the teaching modules Vertiefungsmodul Biotechnologie FG BVT and Angewandete Biotechnologie aus Sicht der Bioverfahrenstechnik.

For those, who are interested in writing a BSc or MSc thesis, we conduct thorough discussions about their previous work and interests in order to identify their strengths and areas in which they can further develop their potential. The most recently started work was in the fields of cell separation of microalgae, sensory analysis of metabolites, cell density measurement in screening processes, etc. → module description

Master and Bachelor theses can be carried out in the Joint Lab Bioelectronics in the fields as listed under "Research". Just contact us if you are interested. Through discussion we will jointly develop a suitable topic that either has to be dealt with for an ongoing research project or that fits your strengths and weaknesses. In the list below - without claiming to be complete - some possible topics are given.

The calls are aimed at students of biotechnology or other life sciences. On the basis of our cooperation with Faculty IV, interested students from electronics and computer science can also apply.

Electrical cell separation in microfluidic channels. The basic effect is dielectrophoresis. For life scientists, the question of its applicability to microalgae and other microorganisms to be investigated arises. From the point of view of electronics and computer science, on the other hand, it is of interest how the electrical cell properties can be determined or how the separation effect can be optimised using machine learning methods.

In-line process sensors. For the lab-of-the-future at the FGBVT, microsensors are being developed and tested that monitor the bioprocess in microtitre plates or minibioreactors. This includes sensors for the monitoring of biomass as well as metabolites. The principle of impedance measurement is used to measure biomass or cell density. For metabolites such as glucose we use special receptor assays such as ConcanavalinA-dextran.

Privacy for medical implants. Chemical sensors e.g. for glucose are on the verge of being used as full implants in medical diagnostics. This opens up completely new perspectives for the therapy of difficult diseases such as diabetes. But what about the privacy of the data obtained? How are the technical systems to be designed so that they meet the strict requirements of the DSGVO, which came into force last year? These questions were discussed in the lecture series "Internet and Privacy" and approaches to solutions are to be examined that are oriented to the development status of fitness trackers.

Electrically driven lysis of cells. In nucleic acid diagnostics, nucleotide strands to be examined must first be isolated from the cells. While detection and sequencing are now miniaturized, this is not yet the case with lysis. The aim of the work is to build a chip-based system that will allow the lysis process to be operated efficiently. At FG Sensorik und Aktuatorik an electronic system based on commercially available components is to be designed and built, and a "passive" chip with Au or TiN electrodes is to be controlled by this system. At FG BVT the system will be tested and protocols for different cell types will be studied to achieve maximum throughput and efficiency.