Angewandte Biochemie


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  • Pinkert, S.; Dieringer, B.; Klopfleisch, R.; Savvatis, K.; Van Linthout, S.; Pryshliak, M.; Tschope, C.; Klingel, K.; Kurreck, J.; Beling, A.; Fechner, H. (2019) Early Treatment of Coxsackievirus B3-Infected Animals with Soluble Coxsackievirus-Adenovirus Receptor Inhibits Development of Chronic Coxsackievirus B3 Cardiomyopathy. Circ. Heart Fail. 12, e005250.
  • Al-Zeer, M.A.; Dutkiewicz, M.; von Hacht, A.; Kreuzmann, D.; Röhrs, V.; Kurreck, J. (2019) Alternatively spliced variants of the 5’-UTR of the ARPC2 mRNA regulate translation by an internal ribosome entry site (IRES) harboring a guanine quadruplex motif. RNA Biol. 16, 1622-1632.
  • Vester, K.; Eravci, M.; Serikawa, T.; Schütze, T.; Weise, C.; Kurreck, J. (2019) RNAi-mediated knockdown of the Rhau helicase preferentially depletes Proteins with a Guanine-quadruplex motif in the 5'-UTR of their mRNA. Biochim. Biophy. Res. Commun. 508, 756-761.
  • Weinhart, M.; Hocke, A.C.; Hippenstiel, S.; Kurreck, J.; Hedtrich, S. (2019) 3D Organ Models - Revolution in Pharmacological Research? Pharmacol. Res. 139, 446-451.
  • Al-Zeer, M.; Kurreck, J. (2019) Deciphering the Enigmatic Biological Functions of RNA Guanine-Quadruplex Motifs in Human Cells. Biochemistry 59, 305-311.



  • Tschope, C.; Muller, I.; Xia, Y.; Savvatis, K.; Pappritz, K.; Pinkert, S.; Lassner, D.; Heimesaat, M.M.; Spillmann, F.; Miteva, K.; Bereswill, S.; Schultheiss, H.P.; Fechner, H.; Pieske, B.; Kuhl, U.; Van Linthout, S. (2018) NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis. Circ Heart Fail 10, e00387.
  • Kurreck, J. (2017) Rethinking Delivery: Viral Vectors and RNA Interference. J. RNAi Gene Silencing 13, 545-547.
  • Serikawa, T.; Eberle, J.; Kurreck, J. (2017) Effects of genomic disruption of a Guanine quadruplex in the 5’ UTR of the Bcl-2 mRNA in melanoma cells. FEBS Lett. 591, 3649-3659.
  • Schaar, K.; Geisler, A.; Kraus, M.; Pinkert, S.; Pryshilak, M.; Spencer, J.F.; Tollefson, A.E.; Ying, B.; Kurreck, J. Wold, W.S.; Klopfleisch, R.; Toth, K.; Fechner, H. (2017) Anti-adenoviral artificial microRNAs expressed from AAV9 vectors inhibit human adenovirus infection in immunosuppressed Syrian hamsters. Mol. Ther. Nucleic Acids 8, 300-316.
  • Ungerechts, G.; Engeland, C.E.; Buchholz, C.J.; Eberle, J.; Fechner, H.; Geletneky, K.; Holm, P.S.; Kreppel, F.; Kuhnel, F.; Lang, K.S. et al. (2017) Virotherapy Research in Germany: From Engineering to Translation. Hum. Gene Ther. 28, 800-819.
  • Hubner, D.; Jahn, K.; Pinkert, S.; Bohnke, J.; Jung, M.; Fechner, H.; Rujescu, D.; Liebert, U.G.; Claus, C. (2017) Infection of iPSC Lines with Miscarriage-Associated Coxsackievirus and Measles Virus and Teratogenic Rubella Virus as a Model for Viral Impairment of Early Human Embryogenesis. ACS Infect. Dis. 3, 886-897.
  • Wagner, A., Kurreck, J. (2017)  Antisense DNA in eukaryotes. In: Reference Module in Life Sciences, Elsevier, ISBN 9780128096338.
  • Fechner,  H., Vetter, R., Kurreck, J., Poller, W. (2017) Silencing genes in the heart: AAV vectors for cardiac gene silencing.  Methods Mol Biol. 1521, 17-39.


  • Schaar, K., Röger, C., Pozzuto, T., Kurreck, J., Pinkert, S., Fechner, H. (2017) Biological antivirals for treatment of adenovirus infections. Antivir Ther. 21, 559-566
  • Pinkert, S., Dieringer, B., Diedrich, S., Zeichhardt, H., Kurreck, J., Fechner, H. (2016) Soluble coxsackie- and adenovirus receptor (sCAR-Fc); a highly efficient compound against laboratory and clinical strains of coxsackie-B-Virus. Antiviral Res. 136, 1-8.
  • Hiller, T., Röhrs, V., Materne, E.-M.; Wagner, A., Fechner, H., Lauster, R., Kurreck, J. (2016) Study of viral vectors in a three-dimensional liver model repopulated with the human hepatocellular carcinoma cell line HepG2. J. Vis. Exp. 116, e54633.
  • Geisler, A., Fechner, H. (2016) MicroRNA-regulated viral vectors for gene therapy. World J. Exp. Med. 6, 37-54.
  • Pinkert, S., Röger, C., Kurreck, J., Bergelson, J., Fechner, H. (2016) The coxsackievirus and adenovirus receptor: glycosylation and the extracellular D2 Domain are not required for coxsackievirus B3 infection. J Virol. 90, 5601-5619.


  • Hoan, N. X., Tong, H. V., Hecht, N., Sy, B. T., Marcinek, P., Meyer, C. G., Song, L. H., Toan, N. L., Kurreck, J., Kremsner, P. G., Bock, C. T., Velavan, T. P. (2015). Hepatitis E virus superinfection and clinical progression in hepatitis B patients. EBioMedicine 2, 2080-2086.
  • Wagner, A., Röhrs, V., Materne, E.-M., Hiller, T., Kedzierski, R., Fechner, H., Lauster, R., Kurreck, J. (2015) Use of a three-dimensional humanized liver model for the study of viral gene vectors. J. Biotechnol. 212, 134–143.
  • Wagner, A., Bock, C.-T., Fechner, H., Kurreck, J. (2015) Application of modified antisense Oligonucleotides and siRNAs as antiviral drugs. Future Med. Chem. 7, 1637–1642.
  • Dutkiewicz, M., Ojdowska, A., Kuczynski, J., Lindig, V., Zeichhardt, H., Kurreck, J., Ciesiołka, J (2015) Targeting Highly Structured RNA by Cooperative Action of siRNAs and Helper Antisense Oligomers in Living Cells. PLoS One 10, e0136395.
  • Schmidt-Lucke, C., Zobel, T., Schrepfer, S., Kuhl, U., Wang, D., Klingel, K., Becher, P.M., Fechner, H., Pozzuto, T., Van Linthout, S., Lassner, D., Spillmann, F., Escher, F., Holinski, S., Volk, H.D., Schultheiss, H.P., Tschope, C. (2015) Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy. J. Infect. Dis. 2012, 1070-1081.
  • Pozzuto, T, Röger, C, Kurreck, J., Fechner, H. (2015) Enhanced suppression of adenovirus replication by triple combination of anti-adenoviral siRNAs, soluble adenovirus receptor trap sCAR-Fc and cidofovir. Antiviral Res. 120, 72-78.
  • Röger, C., Pozzuto, T., Kloppfleisch, R., Kurreck, J., Pinkert, S., Fechner, H. (2015) Expression of an engineered soluble coxsackievirus and adenovirus receptor by a dimeric AAV9 vector inhibits adenovirus infection in mice. Gene Ther. 22, 458-66.
  • Stein, E., Pinkert, S., Becher, M. P., Geisler, A., Zeichhardt, H., Klopfeisch, R., Poller, W., Tschöpe, C., Lassner, D., Fechner, H., Kurreck, J. (2015) Combination of RNA interference and virus receptor trap exerts additive antiviral activity in coxsackievirus B3-induced myocarditis in mice. J. Infect. Dis. 211, 613-622.


  • Milbradt, J., Kraut, A., Hutterer, C., Sonntag, E., Schmeiser, C., Ferro, M., Wagner, S., Lenac, T., Claus, C., Pinkert, S., Hamilton, S.T., Rawlinson, W.D., Stich, H., Coute, Y., Marschall, M. (2014) Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus. Mol Cell Proteomics 13, 2132-2146.
  • Jenke A, Holzhauser L, Löbel M, Savvatis K, Wilk S, Weithäuser A, Pinkert S, Tschöpe C, Klingel K, Poller W, Scheibenbogen C, Schultheiss HP, Skurk C. (2014) Adiponectin promotes coxsackievirus B3 myocarditis by suppression of acute anti-viral immune responses. Basic Res Cardiol. 109, 408.
  • Freiberg F, Sauter M, Pinkert S, Govindarajan T, Kaldrack J, Thakkar M, Fechner H, Klingel K, Gotthardt M. (2014) Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor. J Virol. 88, 7345-7356.
  • von Kietzell K, Pozzuto T, Heilbronn R, Grössl T, Fechner H, Weger S. (2014) Antibody-mediated enhancement (ADE) of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q. J Virol. 88, 8102-8015.
  • Von Hacht, A., Seifert, O.,Menger, M., Schütze, T., Arora, A., Konthur,Z., Neubauer, P., Wagner, A., Weise, C., Kurreck, J. (2014) Identification and characterization of RNA guanine-quadruplex binding proteins. Nucleic Acids Res. 42, 6630-6644.
  • Größl, T., Hammer, E., Bien-Moller, S., Geisler, A., Pinkert, S., Roger, C., Poller, W., Kurreck, J., Volker, U., Vetter, R., Fechner, H. (2014) A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cadiomyocytes Improves Ca2+ Uptake into the Sarcoplasmic Reticulum. PLoS ONE 9, e92188


  • Wagner, A., Röhrs, V., Kedzierski, R., Fechner, H., Kurreck, J. (2013) A novel method for the quantification of adeno-associated virus (AAV) vectors for RNA interference applications using quantitative PCR and purified genomic AAV as a standard. Hum. Gene Ther. Meth. 24, 355-363.
  • Brandt, M. R. G., Kirste, A. G., Pozzuto, T., Schubert, S., Kandolf, R., Fechner, H., Bock, C.-T., Kurreck, J. (2013) Adenovirus-vector mediated RNA interference for the Inhibition of human parvovirus B29 replication. Virus Res. 176, 155-160.
  • Kurreck, J. (2013) Antisense DNA in Eukaryotes. In: Maloy, S., Hughes, K. (Eds.) Brenner's Encyclopedia of Genetics 2nd Edition. Vol 1. Academic Press, San Diego, 153-155.
  • Geisler, A., Schon, C., Grossl, T., Pinkert, S., Stein, E.A., Kurreck, J., Vetter, R., Fechner, H. (2013) Application of Mutated miR-206 Target Sites Enables Skeletal Muscle-specific Silencing of Transgene Expression of Cardiotropic AAV9 Vectors. Mol. Ther. 21, 924-933.
  • Wagner, A., Segler, L., Kleinsteuber, S., Sawers, G., Smidt, H., Lechner, U. (2013) Regulation of reductive dehalogenase gene transcription in Dehalococcoides mccartyi. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 368, 20120317.


  • Wagner, A., Cooper, M., Ferdi, S., Seifert, J., Adrian, L. (2012) Growth of Dehalococcoides mccartyi strain CBDB1 by reductive dehalogenation of brominated benzenes to benzene. Environ. Sci. Technol. 46, 8960-8968.
  • Winter, K., von Kietzell, K., Heilbronn, R., Pozzuto, T., Fechner, H., Weger, S. (2012) Roles of E4orf6 and VA I RNA in adenovirus-mediated stimulation of human parvovirus B19 DNA replication and structural gene expression. J. Virol. 86, 5099-5109.
  • Boltzen, U., Eisenreich, A., Antoniak, S., Weithaeuser, A., Fechner, H., Poller, W., Schultheiss, H.P., Mackman, N., Rauch, U. (2012) Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-alpha-induced apoptosis. J. Mol. Cell. Cardiol. 52, 1056-1065.
  • Kurreck, J. (2012) Oligonucleotide als zellbiologische Werkzeuge. In: Lottspeich, F.; Engels, J. (eds.) Bioanalytik. Spektrum Verlag, 3. Auflage, Heidelberg, Germany, 1059-1076.


  • Geisler, A.; Jungmann, A.; Kurreck, J.; Poller, W.; Katus, H. A.; Vetter, R.; Fechner, H.; Müller, O. J. (2011) microRNA122 Regulated Transgene Expression Increases Specificity of Cardiac Gene Transfer Upon Intravenous Delivery of AAV9 Vectors. Gene Therapy 18, 199-209. [pdf full text]
  • Fechner, H.; Kurreck, J.(2011) Viral vectors for RNA interference applications in cancer research and therapy. In: Kratz, F.; Senter, P.; Steinhagen, H. (Eds.) Drug Delivery in Oncology, Wiley-VCH-Verlag, Weinheim,1415-1442
  • Rothe, D.; Wade, E.; Kurreck, J. (2011) Design of small interfering RNAs for antiviral applications. Methods Mol Biol. 721, 267-292. [pdf full text]
  • Fechner, H.; Pinkert, S.; Geisler, A.; Poller, W.; Kurreck, J. (2011) Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections. Molecules 16, 8475-8503. [pdf full text]
  • Pinkert, S., Klingel, K., Lindig, V., Dörner, A., Zeichhardt, H., Spiller, O.B., and H. Fechner (2011) Virus host co-evolution in a persistent CVB3 infected cardiomyocyte cell line. J. Virol. 85, 13409-13419.
  • Claus, C., S. Chey, S. Heinrich, M. Reins, B. Richardt, S. Pinkert, H. Fechner, F. Gaunitz, I. Schäfer, P. Seibel, and U.G. Liebert. (2011) Involvement of p32 and microtubules in modulation of mitochondrial functions by rubella virus. J. Virol. 85, 3881-3892.
  • Pozzuto, T., K. von Kietzell, T. Bock, C. Schmidt-Lucke, W. Poller, T. Zobel, D. Lassner, H. Zeichhardt, S. Weger, and H. Fechner. (2011) Transactivation of human parvovirus B19 gene expression in endothelial cells by adenoviral helper functions. Virology 411, 50-64.
  • Vetter, R., U. Rehfeld, C. Reissfelder, H. Fechner, H., E. Seppet, and R. Kreutz. (2011) Decreased cardiac SERCA2 expression, SR Ca uptake and contractile function in hypothyroidism are attenuated in SERCA2 overexpressing transgenic rats. Am. J. Physiol - Heart Circ. Physiol. 300, H943-50.
  • Sipo, I., M. Knauf, H. Fechner, W. Poller, O. Planz, R. Kurth, and S. Norley. (2011) Vaccine protection against lethal homologous and heterologous challenge using recombinant AAV vectors expressing codon-optimized genes from pandemic swine origin influenza virus (SOIV). Vaccine 29, 1690-1699.
  • Fecker, L. F., S. Ruckert, B. M. Kurbanov, M. Schmude, E. Stockfleth, H. Fechner, and J. Eberle. (2011) Efficient melanoma cell killing and reduced melanoma growth in mice by a selective replicating adenovirus armed with TNF-related apoptosis inducing ligand. Hum. Gene Ther. 22,405-417.
  • Marco-Urrea, E.; Paul, S.; Khodaverdi, V.; Seifert, J.; von Bergen, M.; Kretzschmar, U.; Adrian, L. (2011) Identification and Characterization of a Re-Citrate Synthase in Dehalococcoides strain CBDBI. J. Bacteriol. 193, 5171-5178


  • Eckstein, A.; Grossl, T.; Geisler, A.; Wang, X.; Pinkert, S.; Pozzuto, T.; Schwer, C.; Kurreck, J.; Weger, S.; Vetter, R.; Poller, W.; Fechner, H. (2010) Inhibition of adenovirus infections by siRNA-mediated silencing of early and late adenoviral gene functions. Antiviral Res. 88, 86-94 [pdf full text]
  • Rothe, D.; Wajant, G.; Grunert, H.-P.; Zeichhardt, H.; Fechner, H.; Kurreck, J. (2010) Rapid construction of Adeno-associated virus (AAV) vectors expressing multiple short hairpin RNAs with high antiviral activity against echovirus 30. Oligonucleotides 20, 191-198. [pdf full text]
  • Kurreck, J. (2010) Proof of RNA interference in humans after systematic delivery of siRNAs. Angew. Chem. Int. Ed. 49, 6258-6259. [abstract]
  • Werk, D.; Wengel, J.; Wengel, S. W.; Grunert, H.P.; Zeichhardt, H.; Kurreck, J. (2009) Application of small interfering RNAs modified by unlocked nucleic acid (UNA) to inhibit the heart-pathogenic coxsackievirus B3. FEBS Lett. 584, 591-598. [pdf full text]
  • Poller, W., Hajjar, R., Schultheiss, H.-P., Fechner, H. (2010). Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure. Cardiovasc Res. 86, 353-364.
  • S. Mern, Demissew; Ha, Seung-Wook; Khodaverdi, V.; Gliese, N.; Görisch, H. (2010) A complex regulatory network controls aerobic ethanol oxidation in Pseudomonas aeruginosa:indication of four levels of sensor kinases and response regulators. Microbiology 156: 1505-1516.
  • Kretzschmar, U.; Khodaverdi, V.; Adrian, L. (2010) Transcriptional regulation of the acetyl-CoA synthetase gene acsA in Pseudomonas aeruginosa. Arch Microbiol. 2010, 685-690.